Submitted by yip4002 on June 5, 2026 - 4:45pm
| Title | Reinforcement learning improves LLM accuracy and reasoning in disease classification from radiology reports. |
| Publication Type | Journal Article |
| Year of Publication | 2026 |
| Authors | Wei Y, Lin Y, Flanders A, Shih G, Peng Y |
| Journal | NPJ Digit Med |
| Date Published | 2026 Apr 30 |
| ISSN | 2398-6352 |
| Abstract | Accurate disease classification from radiology reports is essential for many applications. While supervised fine-tuning (SFT) of lightweight LLMs improves accuracy, it can degrade reasoning. We propose a two-stage approach: SFT on disease labels followed by Group Relative Policy Optimization (GRPO) to refine predictions by optimizing accuracy and format without reasoning supervision. Across three radiologist-annotated datasets, SFT outperformed baselines and GRPO further improved classification and enhanced reasoning recall and comprehensiveness. |
| DOI | 10.1038/s41746-026-02685-4 |
| Alternate Journal | NPJ Digit Med |
| PubMed ID | 42062541 |
| Grant List | 75N920202D00021 / EB / NIBIB NIH HHS / United States 75N920202D00021 / EB / NIBIB NIH HHS / United States 75N920202D00021 / EB / NIBIB NIH HHS / United States 2145640 / / NSF CAREER Award / |
