CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-ray.

TitleCXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-ray.
Publication TypeJournal Article
Year of Publication2025
AuthorsLin M, Holste G, Wang S, Zhou Y, Wei Y, Banerjee I, Chen P, Dai T, Du Y, Dvornek NC, Ge Y, Guo Z, Hanaoka S, Kim D, Messina P, Lu Y, Parra D, Son D, Soto Á, Urooj A, Vidal R, Yamagishi Y, Yan P, Yang Z, Zhang R, Zhou Y, Celi LAnthony, Summers RM, Lu Z, Chen H, Flanders A, Shih G, Wang Z, Peng Y
JournalMed Image Anal
Volume106
Pagination103739
Date Published2025 Dec
ISSN1361-8423
KeywordsHumans, Lung Diseases, Machine Learning, Radiographic Image Interpretation, Computer-Assisted, Radiography, Thoracic
Abstract

The CXR-LT series is a community-driven initiative designed to enhance lung disease classification using chest X-rays (CXR). It tackles challenges in open long-tailed lung disease classification and enhances the measurability of state-of-the-art techniques. The first event, CXR-LT 2023, aimed to achieve these goals by providing high-quality benchmark CXR data for model development and conducting comprehensive evaluations to identify ongoing issues impacting lung disease classification performance. Building on the success of CXR-LT 2023, the CXR-LT 2024 expands the dataset to 377,110 chest X-rays (CXRs) and 45 disease labels, including 19 new rare disease findings. It also introduces a new focus on zero-shot learning to address limitations identified in the previous event. Specifically, CXR-LT 2024 features three tasks: (i) long-tailed classification on a large, noisy test set, (ii) long-tailed classification on a manually annotated "gold standard" subset, and (iii) zero-shot generalization to five previously unseen disease findings. This paper provides an overview of CXR-LT 2024, detailing the data curation process and consolidating state-of-the-art solutions, including the use of multimodal models for rare disease detection, advanced generative approaches to handle noisy labels, and zero-shot learning strategies for unseen diseases. Additionally, the expanded dataset enhances disease coverage to better represent real-world clinical settings, offering a valuable resource for future research. By synthesizing the insights and innovations of participating teams, we aim to advance the development of clinically realistic and generalizable diagnostic models for chest radiography.

DOI10.1016/j.media.2025.103739
Alternate JournalMed Image Anal
PubMed ID40795541
PubMed Central IDPMC12396843
Grant ListR01 LM014306 / LM / NLM NIH HHS / United States
R01 EB017205 / EB / NIBIB NIH HHS / United States
U54 TW012043 / TW / FIC NIH HHS / United States
OT2 OD032701 / OD / NIH HHS / United States
75N92020D00021 / HL / NHLBI NIH HHS / United States